Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture...

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Detalles Bibliográficos
Autores principales: Eyerer, Frederick, Gardner, Juli-Anne, Devitt, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital Universitário da Universidade de São Paulo 2021
Materias:
Clinical Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597805/
https://www.ncbi.nlm.nih.gov/pubmed/34805009
http://dx.doi.org/10.4322/acr.2021.340
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author Eyerer, Frederick
Gardner, Juli-Anne
Devitt, Katherine A.
author_facet Eyerer, Frederick
Gardner, Juli-Anne
Devitt, Katherine A.
author_sort Eyerer, Frederick
collection PubMed
description Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.
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spelling pubmed-85978052021-11-19 Mantle cell lymphoma presenting with lethal atraumatic splenic rupture Eyerer, Frederick Gardner, Juli-Anne Devitt, Katherine A. Autops Case Rep Clinical Case Report Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture. Hospital Universitário da Universidade de São Paulo 2021-11-05 /pmc/articles/PMC8597805/ /pubmed/34805009 http://dx.doi.org/10.4322/acr.2021.340 Text en Copyright: © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Copyright © 2021 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Case Report
Eyerer, Frederick
Gardner, Juli-Anne
Devitt, Katherine A.
Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_full Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_fullStr Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_full_unstemmed Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_short Mantle cell lymphoma presenting with lethal atraumatic splenic rupture
title_sort mantle cell lymphoma presenting with lethal atraumatic splenic rupture
topic Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597805/
https://www.ncbi.nlm.nih.gov/pubmed/34805009
http://dx.doi.org/10.4322/acr.2021.340
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AT devittkatherinea mantlecelllymphomapresentingwithlethalatraumaticsplenicrupture

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