m(5)C Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Papillary Thyroid Carcinoma

Recently, immune response modulation at the epigenetic level is illustrated in studies, but the possible function of RNA 5-methylcytosine (m(5)C) modification in cell infiltration within the tumor microenvironment (TME) is still unclear. Three different m(5)C modification patterns were identified, and high differentiation degree was observed in the cell infiltration features within TME under the above three identified patterns. A low m(5)C-score, which was reflected in the activated immunity, predicted the relatively favorable prognostic outcome. A small amount of effective immune infiltration was seen in the high m(5)C-score subtype, indicating the dismal patient survival. Our study constructed a diagnostic model using the 10 signature genes highly related to the m(5)C-score, discovered that the model exhibited high diagnostic accuracy for PTC, and screened out five potential drugs for PTC based on this m5C-score model. m(5)C modification exerts an important part in forming the TME complexity and diversity. It is valuable to evaluate the m(5)C modification patterns in single tumors, so as to enhance our understanding towards the infiltration characterization in TME.