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Reconciling multiple connectivity scores for drug repurposing
The basis of several recent methods for drug repurposing is the key principle that an efficacious drug will reverse the disease molecular ‘signature’ with minimal side effects. This principle was defined and popularized by the influential ‘connectivity map’ study in 2006 regarding reversal relations...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597919/ https://www.ncbi.nlm.nih.gov/pubmed/34013329 http://dx.doi.org/10.1093/bib/bbab161 |