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GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma

BACKGROUND: Aberrant TAK1 (transforming growth factor β‐activated kinase 1) activity is known to be involved in a variety of malignancies, but the regulatory mechanisms of TAK1 remain poorly understood. GRAMD4 (glucosyltransferase Rab‐like GTPase activator and myotubularin domain containing 4) is a...

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Detalles Bibliográficos
Autores principales:	Ge, Qian yun, Chen, Jin, Li, Gan xun, Tan, Xiao long, Song, Jia, Ning, Deng, Mo, Jie, Du, Peng cheng, Liu, Qiu meng, Liang, Hui fang, Ding, Ze yang, Zhang, Xue wu, Zhang, Bi xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597946/ https://www.ncbi.nlm.nih.gov/pubmed/34841685 http://dx.doi.org/10.1002/ctm2.635

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