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Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition

The KEAP1/NRF2 pathway promotes metabolic rewiring to support redox homeostasis. Activation of NRF2 occurs in many cancers, often due to KEAP1 mutations, and is associated with more aggressive disease and treatment resistance. To identify metabolic dependencies in cancers with NRF2 activation, we pe...

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Detalles Bibliográficos
Autores principales:	Ding, Hongyu, Chen, Zihong, Wu, Katherine, Huang, Shih Ming, Wu, Warren L., LeBoeuf, Sarah E., Pillai, Ray G., Rabinowitz, Joshua D., Papagiannakopoulos, Thales
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598006/ https://www.ncbi.nlm.nih.gov/pubmed/34788087 http://dx.doi.org/10.1126/sciadv.abk1023

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