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Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

Somatic mutations in APC or CTNNB1 genes lead to aberrant Wnt signaling and colorectal cancer (CRC) initiation and progression via-catenin–T cell factor/lymphoid enhancer binding factor TCF/LEF transcription factors. We found that Lef1 was expressed exclusively in Apc-mutant, Wnt ligand–independent...

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Detalles Bibliográficos
Autores principales:	Heino, Sarika, Fang, Shentong, Lähde, Marianne, Högström, Jenny, Nassiri, Sina, Campbell, Andrew, Flanagan, Dustin, Raven, Alexander, Hodder, Michael, Nasreddin, Nadia, Xue, Hai-Hui, Delorenzi, Mauro, Leedham, Simon, Petrova, Tatiana V., Sansom, Owen, Alitalo, Kari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598008/ https://www.ncbi.nlm.nih.gov/pubmed/34788095 http://dx.doi.org/10.1126/sciadv.abj0512

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