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Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
BACKGROUND: Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation following ARF is not well es...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598055/ https://www.ncbi.nlm.nih.gov/pubmed/34788321 http://dx.doi.org/10.1371/journal.pone.0259737 |
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author | da Silva, Telêmaco Luis Pazin-Filho, Antonio Romano, Minna M. D. Ferriani, Virgínia P. L. Marin-Neto, José A. Maciel, Benedito C. Schmidt, André |
author_facet | da Silva, Telêmaco Luis Pazin-Filho, Antonio Romano, Minna M. D. Ferriani, Virgínia P. L. Marin-Neto, José A. Maciel, Benedito C. Schmidt, André |
author_sort | da Silva, Telêmaco Luis |
collection | PubMed |
description | BACKGROUND: Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation following ARF is not well established. OBJECTIVE: To investigate the prognostic value of DEC in patients with ARF as a predictor of chronic valve dysfunction. METHODS: Prospectively enrolled patients with clinical ARF had a DEC performed soon after diagnosis and repeated at 1, 3, 6 and 12 months and thereafter at every 1–2 years. We defined chronic valve dysfunction by ≥ 3 of the following: increased valve thickening, commissure fusion, subvalvular thickening, reduced leaflet mobility, non-trivial mitral and/or aortic regurgitation. We performed univariate analysis and developed multivariate logistic regression models to identify variables that may influence evolution to RHD. p <0.05 was considered significant. RESULTS: We evaluated 70(57% men) patients, 10.8±5.6 years-old during the ARF episode and followed for 95±26 months. Chronic valve dysfunction was identified in 36(51.4%) which fulfilled criteria for RHD and 10(27.8%) of them died or underwent valve surgery. Univariate analysis showed that mitral valve thickening and presence of mitral regurgitation at baseline DEC, were associated with RHD(p<0.01). Multivariate logistic regression showed that only mitral valve thickness either as a continuous (Odds-Ratio:5.8;95%CI:1.7–19.7) or as a categorical variable (Odds-Ratio:4.04;95%CI:1.06–15.3) was an independent predictor of chronic valve dysfunction. CONCLUSIONS: Mitral leaflets thickening documented at the time of diagnosis of ARF is a consistent prognostic marker for the subsequent evolution to RHD. |
format | Online Article Text |
id | pubmed-8598055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85980552021-11-18 Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction da Silva, Telêmaco Luis Pazin-Filho, Antonio Romano, Minna M. D. Ferriani, Virgínia P. L. Marin-Neto, José A. Maciel, Benedito C. Schmidt, André PLoS One Research Article BACKGROUND: Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation following ARF is not well established. OBJECTIVE: To investigate the prognostic value of DEC in patients with ARF as a predictor of chronic valve dysfunction. METHODS: Prospectively enrolled patients with clinical ARF had a DEC performed soon after diagnosis and repeated at 1, 3, 6 and 12 months and thereafter at every 1–2 years. We defined chronic valve dysfunction by ≥ 3 of the following: increased valve thickening, commissure fusion, subvalvular thickening, reduced leaflet mobility, non-trivial mitral and/or aortic regurgitation. We performed univariate analysis and developed multivariate logistic regression models to identify variables that may influence evolution to RHD. p <0.05 was considered significant. RESULTS: We evaluated 70(57% men) patients, 10.8±5.6 years-old during the ARF episode and followed for 95±26 months. Chronic valve dysfunction was identified in 36(51.4%) which fulfilled criteria for RHD and 10(27.8%) of them died or underwent valve surgery. Univariate analysis showed that mitral valve thickening and presence of mitral regurgitation at baseline DEC, were associated with RHD(p<0.01). Multivariate logistic regression showed that only mitral valve thickness either as a continuous (Odds-Ratio:5.8;95%CI:1.7–19.7) or as a categorical variable (Odds-Ratio:4.04;95%CI:1.06–15.3) was an independent predictor of chronic valve dysfunction. CONCLUSIONS: Mitral leaflets thickening documented at the time of diagnosis of ARF is a consistent prognostic marker for the subsequent evolution to RHD. Public Library of Science 2021-11-17 /pmc/articles/PMC8598055/ /pubmed/34788321 http://dx.doi.org/10.1371/journal.pone.0259737 Text en © 2021 da Silva et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article da Silva, Telêmaco Luis Pazin-Filho, Antonio Romano, Minna M. D. Ferriani, Virgínia P. L. Marin-Neto, José A. Maciel, Benedito C. Schmidt, André Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
title | Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
title_full | Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
title_fullStr | Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
title_full_unstemmed | Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
title_short | Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
title_sort | mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598055/ https://www.ncbi.nlm.nih.gov/pubmed/34788321 http://dx.doi.org/10.1371/journal.pone.0259737 |
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