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Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent

Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first descriptio...

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Autores principales: Bellomo, Carla, Alonso, Daniel Oscar, Ricardo, Tamara, Coelho, Rocío, Kehl, Sebastián, Periolo, Natalia, Azogaray, Viviana, Casas, Natalia, Ottonelli, Mariano, Bergero, Laura Cristina, Cudós, María Carolina, Previtali, María Andrea, Martinez, Valeria Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598061/
https://www.ncbi.nlm.nih.gov/pubmed/34788281
http://dx.doi.org/10.1371/journal.pntd.0009842
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author Bellomo, Carla
Alonso, Daniel Oscar
Ricardo, Tamara
Coelho, Rocío
Kehl, Sebastián
Periolo, Natalia
Azogaray, Viviana
Casas, Natalia
Ottonelli, Mariano
Bergero, Laura Cristina
Cudós, María Carolina
Previtali, María Andrea
Martinez, Valeria Paula
author_facet Bellomo, Carla
Alonso, Daniel Oscar
Ricardo, Tamara
Coelho, Rocío
Kehl, Sebastián
Periolo, Natalia
Azogaray, Viviana
Casas, Natalia
Ottonelli, Mariano
Bergero, Laura Cristina
Cudós, María Carolina
Previtali, María Andrea
Martinez, Valeria Paula
author_sort Bellomo, Carla
collection PubMed
description Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported in Argentina. Until now, Alto Paraguay virus was considered a non-pathogenic orthohantavirus since it was identified in a rodent, Holochilus chacarius. In addition to this, with the goal of identifying potential hantavirus host species in the province of Santa Fe, we finally describe a novel orthohantavirus found in the native rodent Scapteromys aquaticus, which differed from other hantaviruses described in the country so far. Our findings implicate an epidemiological warning regarding these new orthohantaviruses circulating in Central Argentina as well as new rodent species that must be considered as hosts from now on.
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spelling pubmed-85980612021-11-18 Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent Bellomo, Carla Alonso, Daniel Oscar Ricardo, Tamara Coelho, Rocío Kehl, Sebastián Periolo, Natalia Azogaray, Viviana Casas, Natalia Ottonelli, Mariano Bergero, Laura Cristina Cudós, María Carolina Previtali, María Andrea Martinez, Valeria Paula PLoS Negl Trop Dis Research Article Orthohantaviruses are emerging rodent-borne pathogens that cause Hantavirus Pulmonary Syndrome in humans. They have a wide range of rodent reservoir hosts and are transmitted to humans through aerosolized viral particles generated by the excretions of infected individuals. Since the first description of HPS in Argentina, new hantaviruses have been reported throughout the country, most of which are pathogenic to humans. We present here the first HPS case infected with Alto Paraguay virus reported in Argentina. Until now, Alto Paraguay virus was considered a non-pathogenic orthohantavirus since it was identified in a rodent, Holochilus chacarius. In addition to this, with the goal of identifying potential hantavirus host species in the province of Santa Fe, we finally describe a novel orthohantavirus found in the native rodent Scapteromys aquaticus, which differed from other hantaviruses described in the country so far. Our findings implicate an epidemiological warning regarding these new orthohantaviruses circulating in Central Argentina as well as new rodent species that must be considered as hosts from now on. Public Library of Science 2021-11-17 /pmc/articles/PMC8598061/ /pubmed/34788281 http://dx.doi.org/10.1371/journal.pntd.0009842 Text en © 2021 Bellomo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bellomo, Carla
Alonso, Daniel Oscar
Ricardo, Tamara
Coelho, Rocío
Kehl, Sebastián
Periolo, Natalia
Azogaray, Viviana
Casas, Natalia
Ottonelli, Mariano
Bergero, Laura Cristina
Cudós, María Carolina
Previtali, María Andrea
Martinez, Valeria Paula
Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_full Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_fullStr Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_full_unstemmed Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_short Emerging hantaviruses in Central Argentina: First case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay virus, and a novel orthohantavirus in Scapteromys aquaticus rodent
title_sort emerging hantaviruses in central argentina: first case of hantavirus pulmonary syndrome caused by alto paraguay virus, and a novel orthohantavirus in scapteromys aquaticus rodent
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598061/
https://www.ncbi.nlm.nih.gov/pubmed/34788281
http://dx.doi.org/10.1371/journal.pntd.0009842
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