A defective viral genome strategy elicits broad protective immunity against respiratory viruses

RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal or intranasal administration of this genom...

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Detalles Bibliográficos
Autores principales: Xiao, Yinghong, Lidsky, Peter V., Shirogane, Yuta, Aviner, Ranen, Wu, Chien-Ting, Li, Weiyi, Zheng, Weihao, Talbot, Dale, Catching, Adam, Doitsh, Gilad, Su, Weiheng, Gekko, Colby E., Nayak, Arabinda, Ernst, Joel D., Brodsky, Leonid, Brodsky, Elia, Rousseau, Elsa, Capponi, Sara, Bianco, Simone, Nakamura, Robert, Jackson, Peter K., Frydman, Judith, Andino, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598942/
https://www.ncbi.nlm.nih.gov/pubmed/34852237
http://dx.doi.org/10.1016/j.cell.2021.11.023

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