Treatments for COVID-19: Lessons from 2020 and new therapeutic options

To face the COVID-19 pandemic, prophylactic vaccines have been developed in record time, but vaccine coverage is still limited, accessibility is not equitable worldwide, and the vaccines are not fully effective against emerging variants. Therefore, therapeutic treatments are urgently needed to contr...

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Autores principales: Salasc, Fanny, Lahlali, Thomas, Laurent, Emilie, Rosa-Calatrava, Manuel, Pizzorno, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598952/
https://www.ncbi.nlm.nih.gov/pubmed/34915400
http://dx.doi.org/10.1016/j.coph.2021.11.002
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author Salasc, Fanny
Lahlali, Thomas
Laurent, Emilie
Rosa-Calatrava, Manuel
Pizzorno, Andrés
author_facet Salasc, Fanny
Lahlali, Thomas
Laurent, Emilie
Rosa-Calatrava, Manuel
Pizzorno, Andrés
author_sort Salasc, Fanny
collection PubMed
description To face the COVID-19 pandemic, prophylactic vaccines have been developed in record time, but vaccine coverage is still limited, accessibility is not equitable worldwide, and the vaccines are not fully effective against emerging variants. Therefore, therapeutic treatments are urgently needed to control the pandemic and treat vulnerable populations, but despite all efforts made, options remain scarce. However, the knowledge gained during 2020 constitutes an invaluable platform from which to build future therapies. In this review, we highlight the main drug repurposing strategies and achievements made over the first 18 months of the pandemic, but also discuss the antivirals, immunomodulators and drug combinations that could be used in the near future to cure COVID-19.
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spelling pubmed-85989522021-11-18 Treatments for COVID-19: Lessons from 2020 and new therapeutic options Salasc, Fanny Lahlali, Thomas Laurent, Emilie Rosa-Calatrava, Manuel Pizzorno, Andrés Curr Opin Pharmacol Article To face the COVID-19 pandemic, prophylactic vaccines have been developed in record time, but vaccine coverage is still limited, accessibility is not equitable worldwide, and the vaccines are not fully effective against emerging variants. Therefore, therapeutic treatments are urgently needed to control the pandemic and treat vulnerable populations, but despite all efforts made, options remain scarce. However, the knowledge gained during 2020 constitutes an invaluable platform from which to build future therapies. In this review, we highlight the main drug repurposing strategies and achievements made over the first 18 months of the pandemic, but also discuss the antivirals, immunomodulators and drug combinations that could be used in the near future to cure COVID-19. The Author(s). Published by Elsevier Ltd. 2022-02 2021-11-18 /pmc/articles/PMC8598952/ /pubmed/34915400 http://dx.doi.org/10.1016/j.coph.2021.11.002 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Salasc, Fanny
Lahlali, Thomas
Laurent, Emilie
Rosa-Calatrava, Manuel
Pizzorno, Andrés
Treatments for COVID-19: Lessons from 2020 and new therapeutic options
title Treatments for COVID-19: Lessons from 2020 and new therapeutic options
title_full Treatments for COVID-19: Lessons from 2020 and new therapeutic options
title_fullStr Treatments for COVID-19: Lessons from 2020 and new therapeutic options
title_full_unstemmed Treatments for COVID-19: Lessons from 2020 and new therapeutic options
title_short Treatments for COVID-19: Lessons from 2020 and new therapeutic options
title_sort treatments for covid-19: lessons from 2020 and new therapeutic options
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598952/
https://www.ncbi.nlm.nih.gov/pubmed/34915400
http://dx.doi.org/10.1016/j.coph.2021.11.002
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