B cell-derived GABA elicits IL-10(+) macrophages to limit anti-tumour immunity

Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu(1–3). Here we identify the metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized...

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Detalles Bibliográficos
Autores principales: Zhang, Baihao, Vogelzang, Alexis, Miyajima, Michio, Sugiura, Yuki, Wu, Yibo, Chamoto, Kenji, Nakano, Rei, Hatae, Ryusuke, Menzies, Rosemary J., Sonomura, Kazuhiro, Hojo, Nozomi, Ogawa, Taisaku, Kobayashi, Wakana, Tsutsui, Yumi, Yamamoto, Sachiko, Maruya, Mikako, Narushima, Seiko, Suzuki, Keiichiro, Sugiya, Hiroshi, Murakami, Kosaku, Hashimoto, Motomu, Ueno, Hideki, Kobayashi, Takashi, Ito, Katsuhiro, Hirano, Tomoko, Shiroguchi, Katsuyuki, Matsuda, Fumihiko, Suematsu, Makoto, Honjo, Tasuku, Fagarasan, Sidonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599023/
https://www.ncbi.nlm.nih.gov/pubmed/34732892
http://dx.doi.org/10.1038/s41586-021-04082-1

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