Characterization of Recombinant Chimpanzee Adenovirus C68 Low and High-Density Particles: Impact on Determination of Viral Particle Titer

We observed differential infectivity and product yield between two recombinant chimpanzee adenovirus C68 constructs whose primary difference was genome length. To determine a possible reason for this outcome, we characterized the proportion and composition of the empty and packaged capsids. Both ana...

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Detalles Bibliográficos
Autores principales: Mullins, Elise K., Powers, Thomas W., Zobel, Jim, Clawson, Kory M., Barnes, Lauren F., Draper, Benjamin E., Zou, Qin, Binder, Joseph J., Dai, Stanley, Zhang, Kun, Friese, Olga, Runnels, Herbert A., Jarrold, Martin F., Thompson, Lawrence C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599148/
https://www.ncbi.nlm.nih.gov/pubmed/34805110
http://dx.doi.org/10.3389/fbioe.2021.753480

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