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Altered functional connectivity during face processing in children born with very low birth weight
Structural brain alterations have been reported in key emotional face processing regions following preterm birth; however, few studies have investigated the functional networks underlying these processes in children born with very low birth weight (VLBW). Using magnetoencephalography (MEG), we exami...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599272/ https://www.ncbi.nlm.nih.gov/pubmed/34089054 http://dx.doi.org/10.1093/scan/nsab070 |
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author | Sato, Julie Safar, Kristina Vandewouw, Marlee M Bando, Nicole O’Connor, Deborah L Unger, Sharon L Taylor, Margot J |
author_facet | Sato, Julie Safar, Kristina Vandewouw, Marlee M Bando, Nicole O’Connor, Deborah L Unger, Sharon L Taylor, Margot J |
author_sort | Sato, Julie |
collection | PubMed |
description | Structural brain alterations have been reported in key emotional face processing regions following preterm birth; however, few studies have investigated the functional networks underlying these processes in children born with very low birth weight (VLBW). Using magnetoencephalography (MEG), we examined the functional networks related to the implicit processing of happy and angry faces in 5-year-old VLBW (n = 28) and full-term (FT; n = 24) children. We found that VLBW children showed atypical recruitment of emotional face processing networks in theta (4–7 Hz) compared to FT children. VLBW children showed reduced theta connectivity during processing of angry faces only. This hypo-connected theta-band network was anchored in the left orbitofrontal and parietal regions, involved in the higher level processing of faces and emotion regulation. At the behavioural level, despite VLBW children performing within the normal range, FT children had significantly higher affect recognition scores. Our MEG results suggest a selective impairment in processing angry faces, which would negatively impact social functioning in VLBW children. In FT children, greater recruitment of this theta-band network was positively associated with improved affect recognition scores. Thus, our findings suggest an important role of theta oscillations in early face processing, deficits which may contribute to broader socio-emotional impairments in VLBW children. |
format | Online Article Text |
id | pubmed-8599272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-85992722021-11-18 Altered functional connectivity during face processing in children born with very low birth weight Sato, Julie Safar, Kristina Vandewouw, Marlee M Bando, Nicole O’Connor, Deborah L Unger, Sharon L Taylor, Margot J Soc Cogn Affect Neurosci Original Manuscript Structural brain alterations have been reported in key emotional face processing regions following preterm birth; however, few studies have investigated the functional networks underlying these processes in children born with very low birth weight (VLBW). Using magnetoencephalography (MEG), we examined the functional networks related to the implicit processing of happy and angry faces in 5-year-old VLBW (n = 28) and full-term (FT; n = 24) children. We found that VLBW children showed atypical recruitment of emotional face processing networks in theta (4–7 Hz) compared to FT children. VLBW children showed reduced theta connectivity during processing of angry faces only. This hypo-connected theta-band network was anchored in the left orbitofrontal and parietal regions, involved in the higher level processing of faces and emotion regulation. At the behavioural level, despite VLBW children performing within the normal range, FT children had significantly higher affect recognition scores. Our MEG results suggest a selective impairment in processing angry faces, which would negatively impact social functioning in VLBW children. In FT children, greater recruitment of this theta-band network was positively associated with improved affect recognition scores. Thus, our findings suggest an important role of theta oscillations in early face processing, deficits which may contribute to broader socio-emotional impairments in VLBW children. Oxford University Press 2021-06-18 /pmc/articles/PMC8599272/ /pubmed/34089054 http://dx.doi.org/10.1093/scan/nsab070 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Manuscript Sato, Julie Safar, Kristina Vandewouw, Marlee M Bando, Nicole O’Connor, Deborah L Unger, Sharon L Taylor, Margot J Altered functional connectivity during face processing in children born with very low birth weight |
title | Altered functional connectivity during face processing in children born with very low birth weight |
title_full | Altered functional connectivity during face processing in children born with very low birth weight |
title_fullStr | Altered functional connectivity during face processing in children born with very low birth weight |
title_full_unstemmed | Altered functional connectivity during face processing in children born with very low birth weight |
title_short | Altered functional connectivity during face processing in children born with very low birth weight |
title_sort | altered functional connectivity during face processing in children born with very low birth weight |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599272/ https://www.ncbi.nlm.nih.gov/pubmed/34089054 http://dx.doi.org/10.1093/scan/nsab070 |
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