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RNA methylation in mammalian development and cancer

Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA modifications) have emerged as crucial regulators in temporal and spatial gene expression during eukaryotic development. To date, over 170 diverse types of chemical modifications have been identified upon RNA n...

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Detalles Bibliográficos
Autores principales: Song, Peizhe, Tayier, Subiding, Cai, Zhihe, Jia, Guifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599391/
https://www.ncbi.nlm.nih.gov/pubmed/34272618
http://dx.doi.org/10.1007/s10565-021-09627-8
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author Song, Peizhe
Tayier, Subiding
Cai, Zhihe
Jia, Guifang
author_facet Song, Peizhe
Tayier, Subiding
Cai, Zhihe
Jia, Guifang
author_sort Song, Peizhe
collection PubMed
description Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA modifications) have emerged as crucial regulators in temporal and spatial gene expression during eukaryotic development. To date, over 170 diverse types of chemical modifications have been identified upon RNA nucleobases. Some of these post-synthesized modifications can be reversibly installed, removed, and decoded by their specific cellular components and play critical roles in different biological processes. Accordingly, dysregulation of RNA modification effectors is tightly orchestrated with developmental processes. Here, we particularly focus on three well-studied RNA modifications, including N(6)-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), and N(1)-methyladenosine (m(1)A), and summarize recent knowledge of underlying mechanisms and critical roles of these RNA modifications in stem cell fate determination, embryonic development, and cancer progression, providing a better understanding of the whole association between epitranscriptomic regulation and mammalian development.
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spelling pubmed-85993912021-11-24 RNA methylation in mammalian development and cancer Song, Peizhe Tayier, Subiding Cai, Zhihe Jia, Guifang Cell Biol Toxicol Review Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA modifications) have emerged as crucial regulators in temporal and spatial gene expression during eukaryotic development. To date, over 170 diverse types of chemical modifications have been identified upon RNA nucleobases. Some of these post-synthesized modifications can be reversibly installed, removed, and decoded by their specific cellular components and play critical roles in different biological processes. Accordingly, dysregulation of RNA modification effectors is tightly orchestrated with developmental processes. Here, we particularly focus on three well-studied RNA modifications, including N(6)-methyladenosine (m(6)A), 5-methylcytosine (m(5)C), and N(1)-methyladenosine (m(1)A), and summarize recent knowledge of underlying mechanisms and critical roles of these RNA modifications in stem cell fate determination, embryonic development, and cancer progression, providing a better understanding of the whole association between epitranscriptomic regulation and mammalian development. Springer Netherlands 2021-07-17 2021 /pmc/articles/PMC8599391/ /pubmed/34272618 http://dx.doi.org/10.1007/s10565-021-09627-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Song, Peizhe
Tayier, Subiding
Cai, Zhihe
Jia, Guifang
RNA methylation in mammalian development and cancer
title RNA methylation in mammalian development and cancer
title_full RNA methylation in mammalian development and cancer
title_fullStr RNA methylation in mammalian development and cancer
title_full_unstemmed RNA methylation in mammalian development and cancer
title_short RNA methylation in mammalian development and cancer
title_sort rna methylation in mammalian development and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599391/
https://www.ncbi.nlm.nih.gov/pubmed/34272618
http://dx.doi.org/10.1007/s10565-021-09627-8
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