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Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
BACKGROUND: The aim was to assess the prognostic value of the newly proposed prognostic index (PI) in patients with p16-positive oropharyngeal squamous cell carcinoma. METHODS: Patients treated with primary surgery from 2012 to 2019 with available preoperative (0–2 days) values of C‑reactive protein...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599407/ https://www.ncbi.nlm.nih.gov/pubmed/34143263 http://dx.doi.org/10.1007/s00508-021-01885-0 |
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author | Brkic, Faris F. Mayer, Christina Besser, Gerold Altorjai, Gabriela Herrmann, Harald Heiduschka, Gregor Haymerle, Georg Kadletz-Wanke, Lorenz |
author_facet | Brkic, Faris F. Mayer, Christina Besser, Gerold Altorjai, Gabriela Herrmann, Harald Heiduschka, Gregor Haymerle, Georg Kadletz-Wanke, Lorenz |
author_sort | Brkic, Faris F. |
collection | PubMed |
description | BACKGROUND: The aim was to assess the prognostic value of the newly proposed prognostic index (PI) in patients with p16-positive oropharyngeal squamous cell carcinoma. METHODS: Patients treated with primary surgery from 2012 to 2019 with available preoperative (0–2 days) values of C‑reactive protein and white blood cell counts needed for calculation of the PI, were included. Main outcome measures were overall survival (OS) and disease-free survival (DFS). The PI was dichotomized into low (PI = 0) and high (PI ≥ 1). RESULTS: In this study 36 patients were included. Average overall (OS) and disease-free survival (DFS) were 3.3 years (range 0.2–12.3 years) and 2.8 years (0.0–9.8 years), respectively. The overall mortality was 16.7% (n = 6) and a recurrent disease was observed in 30.6% of patients (n = 11). Low PI was associated with better overall survival (mean OS 10.1 ± 1.4 years, 95% confidence interval, CI 7.3–12.9 years vs. 1.9 ± 0.4, 95% CI 1.3–2.6 years, p < 0.01; mean DFS 8.5 ± 0.7 years, 95% CI 7.1–9.6 years vs. 1.0 ± 0.3 years, 95% CI 0.5–1.5 years, p < 0.01). CONCLUSION: The PI might be an easily obtainable outcome prognosticator in p16-positive oropharyngeal squamous cell carcinoma patients. Analyzing routinely obtained blood samples can contribute to identifying high-risk patients. |
format | Online Article Text |
id | pubmed-8599407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-85994072021-11-24 Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma Brkic, Faris F. Mayer, Christina Besser, Gerold Altorjai, Gabriela Herrmann, Harald Heiduschka, Gregor Haymerle, Georg Kadletz-Wanke, Lorenz Wien Klin Wochenschr Original Article BACKGROUND: The aim was to assess the prognostic value of the newly proposed prognostic index (PI) in patients with p16-positive oropharyngeal squamous cell carcinoma. METHODS: Patients treated with primary surgery from 2012 to 2019 with available preoperative (0–2 days) values of C‑reactive protein and white blood cell counts needed for calculation of the PI, were included. Main outcome measures were overall survival (OS) and disease-free survival (DFS). The PI was dichotomized into low (PI = 0) and high (PI ≥ 1). RESULTS: In this study 36 patients were included. Average overall (OS) and disease-free survival (DFS) were 3.3 years (range 0.2–12.3 years) and 2.8 years (0.0–9.8 years), respectively. The overall mortality was 16.7% (n = 6) and a recurrent disease was observed in 30.6% of patients (n = 11). Low PI was associated with better overall survival (mean OS 10.1 ± 1.4 years, 95% confidence interval, CI 7.3–12.9 years vs. 1.9 ± 0.4, 95% CI 1.3–2.6 years, p < 0.01; mean DFS 8.5 ± 0.7 years, 95% CI 7.1–9.6 years vs. 1.0 ± 0.3 years, 95% CI 0.5–1.5 years, p < 0.01). CONCLUSION: The PI might be an easily obtainable outcome prognosticator in p16-positive oropharyngeal squamous cell carcinoma patients. Analyzing routinely obtained blood samples can contribute to identifying high-risk patients. Springer Vienna 2021-06-18 2021 /pmc/articles/PMC8599407/ /pubmed/34143263 http://dx.doi.org/10.1007/s00508-021-01885-0 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Brkic, Faris F. Mayer, Christina Besser, Gerold Altorjai, Gabriela Herrmann, Harald Heiduschka, Gregor Haymerle, Georg Kadletz-Wanke, Lorenz Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
title | Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
title_full | Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
title_fullStr | Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
title_full_unstemmed | Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
title_short | Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
title_sort | potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599407/ https://www.ncbi.nlm.nih.gov/pubmed/34143263 http://dx.doi.org/10.1007/s00508-021-01885-0 |
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