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Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma

BACKGROUND: The aim was to assess the prognostic value of the newly proposed prognostic index (PI) in patients with p16-positive oropharyngeal squamous cell carcinoma. METHODS: Patients treated with primary surgery from 2012 to 2019 with available preoperative (0–2 days) values of C‑reactive protein...

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Autores principales: Brkic, Faris F., Mayer, Christina, Besser, Gerold, Altorjai, Gabriela, Herrmann, Harald, Heiduschka, Gregor, Haymerle, Georg, Kadletz-Wanke, Lorenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599407/
https://www.ncbi.nlm.nih.gov/pubmed/34143263
http://dx.doi.org/10.1007/s00508-021-01885-0
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author Brkic, Faris F.
Mayer, Christina
Besser, Gerold
Altorjai, Gabriela
Herrmann, Harald
Heiduschka, Gregor
Haymerle, Georg
Kadletz-Wanke, Lorenz
author_facet Brkic, Faris F.
Mayer, Christina
Besser, Gerold
Altorjai, Gabriela
Herrmann, Harald
Heiduschka, Gregor
Haymerle, Georg
Kadletz-Wanke, Lorenz
author_sort Brkic, Faris F.
collection PubMed
description BACKGROUND: The aim was to assess the prognostic value of the newly proposed prognostic index (PI) in patients with p16-positive oropharyngeal squamous cell carcinoma. METHODS: Patients treated with primary surgery from 2012 to 2019 with available preoperative (0–2 days) values of C‑reactive protein and white blood cell counts needed for calculation of the PI, were included. Main outcome measures were overall survival (OS) and disease-free survival (DFS). The PI was dichotomized into low (PI = 0) and high (PI ≥ 1). RESULTS: In this study 36 patients were included. Average overall (OS) and disease-free survival (DFS) were 3.3 years (range 0.2–12.3 years) and 2.8 years (0.0–9.8 years), respectively. The overall mortality was 16.7% (n = 6) and a recurrent disease was observed in 30.6% of patients (n = 11). Low PI was associated with better overall survival (mean OS 10.1 ± 1.4 years, 95% confidence interval, CI 7.3–12.9 years vs. 1.9 ± 0.4, 95% CI 1.3–2.6 years, p < 0.01; mean DFS 8.5 ± 0.7 years, 95% CI 7.1–9.6 years vs. 1.0 ± 0.3 years, 95% CI 0.5–1.5 years, p < 0.01). CONCLUSION: The PI might be an easily obtainable outcome prognosticator in p16-positive oropharyngeal squamous cell carcinoma patients. Analyzing routinely obtained blood samples can contribute to identifying high-risk patients.
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spelling pubmed-85994072021-11-24 Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma Brkic, Faris F. Mayer, Christina Besser, Gerold Altorjai, Gabriela Herrmann, Harald Heiduschka, Gregor Haymerle, Georg Kadletz-Wanke, Lorenz Wien Klin Wochenschr Original Article BACKGROUND: The aim was to assess the prognostic value of the newly proposed prognostic index (PI) in patients with p16-positive oropharyngeal squamous cell carcinoma. METHODS: Patients treated with primary surgery from 2012 to 2019 with available preoperative (0–2 days) values of C‑reactive protein and white blood cell counts needed for calculation of the PI, were included. Main outcome measures were overall survival (OS) and disease-free survival (DFS). The PI was dichotomized into low (PI = 0) and high (PI ≥ 1). RESULTS: In this study 36 patients were included. Average overall (OS) and disease-free survival (DFS) were 3.3 years (range 0.2–12.3 years) and 2.8 years (0.0–9.8 years), respectively. The overall mortality was 16.7% (n = 6) and a recurrent disease was observed in 30.6% of patients (n = 11). Low PI was associated with better overall survival (mean OS 10.1 ± 1.4 years, 95% confidence interval, CI 7.3–12.9 years vs. 1.9 ± 0.4, 95% CI 1.3–2.6 years, p < 0.01; mean DFS 8.5 ± 0.7 years, 95% CI 7.1–9.6 years vs. 1.0 ± 0.3 years, 95% CI 0.5–1.5 years, p < 0.01). CONCLUSION: The PI might be an easily obtainable outcome prognosticator in p16-positive oropharyngeal squamous cell carcinoma patients. Analyzing routinely obtained blood samples can contribute to identifying high-risk patients. Springer Vienna 2021-06-18 2021 /pmc/articles/PMC8599407/ /pubmed/34143263 http://dx.doi.org/10.1007/s00508-021-01885-0 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Brkic, Faris F.
Mayer, Christina
Besser, Gerold
Altorjai, Gabriela
Herrmann, Harald
Heiduschka, Gregor
Haymerle, Georg
Kadletz-Wanke, Lorenz
Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
title Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
title_full Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
title_fullStr Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
title_full_unstemmed Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
title_short Potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
title_sort potential association of the prognostic index and survival in patients with p16-positive oropharyngeal squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599407/
https://www.ncbi.nlm.nih.gov/pubmed/34143263
http://dx.doi.org/10.1007/s00508-021-01885-0
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