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Corneal ectasia in mothers of Down syndrome children
In this study, corneal findings regarding keratoconus (KC) and early KC among mothers with Down syndrome children (MDS) and a group of age-at-delivery-matched mothers with normal children (MNC) were compared. KC was diagnosed based on the presence of a clinical sign and at least one abnormal tomogra...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599422/ https://www.ncbi.nlm.nih.gov/pubmed/34789864 http://dx.doi.org/10.1038/s41598-021-02035-2 |
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author | Hashemi, Hassan Asgari, Soheila Panahi, Parsa Mehravaran, Shiva Fotouhi, Akbar Ambrósio, Renato |
author_facet | Hashemi, Hassan Asgari, Soheila Panahi, Parsa Mehravaran, Shiva Fotouhi, Akbar Ambrósio, Renato |
author_sort | Hashemi, Hassan |
collection | PubMed |
description | In this study, corneal findings regarding keratoconus (KC) and early KC among mothers with Down syndrome children (MDS) and a group of age-at-delivery-matched mothers with normal children (MNC) were compared. KC was diagnosed based on the presence of a clinical sign and at least one abnormal tomographic or biomechanical criterion. Early KC was defined as having no clinical sign in the presence of at least one abnormal tomographic or biomechanical criterion. The normal subgroups in each group were compared in terms tomographic and biomechanical parameters. In MDS and MNC, the prevalence rates were 6.5% and 1.6% for KC (P = 0.047), and 30.9% and 14.3% for early KC (P = 0.014), respectively. Comparison between the two normal subgroups showed significant differences in mean index of height asymmetry, irregularity index, anterior asphericity, pentacam random forest index, corneal stiffness parameters at first applanation, deformation amplitude ratios, integrated radius-1 mm, highest concavity deflection amplitude, biomechanical corrected IOP, peak distance, and radius (all P < 0.05). This study showed that MDS are more likely to have KC and also to have thinner, steeper and softer corneas compared to MNC. This results support the need for further work for determining the risk of delivering a child with DS. |
format | Online Article Text |
id | pubmed-8599422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85994222021-11-19 Corneal ectasia in mothers of Down syndrome children Hashemi, Hassan Asgari, Soheila Panahi, Parsa Mehravaran, Shiva Fotouhi, Akbar Ambrósio, Renato Sci Rep Article In this study, corneal findings regarding keratoconus (KC) and early KC among mothers with Down syndrome children (MDS) and a group of age-at-delivery-matched mothers with normal children (MNC) were compared. KC was diagnosed based on the presence of a clinical sign and at least one abnormal tomographic or biomechanical criterion. Early KC was defined as having no clinical sign in the presence of at least one abnormal tomographic or biomechanical criterion. The normal subgroups in each group were compared in terms tomographic and biomechanical parameters. In MDS and MNC, the prevalence rates were 6.5% and 1.6% for KC (P = 0.047), and 30.9% and 14.3% for early KC (P = 0.014), respectively. Comparison between the two normal subgroups showed significant differences in mean index of height asymmetry, irregularity index, anterior asphericity, pentacam random forest index, corneal stiffness parameters at first applanation, deformation amplitude ratios, integrated radius-1 mm, highest concavity deflection amplitude, biomechanical corrected IOP, peak distance, and radius (all P < 0.05). This study showed that MDS are more likely to have KC and also to have thinner, steeper and softer corneas compared to MNC. This results support the need for further work for determining the risk of delivering a child with DS. Nature Publishing Group UK 2021-11-17 /pmc/articles/PMC8599422/ /pubmed/34789864 http://dx.doi.org/10.1038/s41598-021-02035-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hashemi, Hassan Asgari, Soheila Panahi, Parsa Mehravaran, Shiva Fotouhi, Akbar Ambrósio, Renato Corneal ectasia in mothers of Down syndrome children |
title | Corneal ectasia in mothers of Down syndrome children |
title_full | Corneal ectasia in mothers of Down syndrome children |
title_fullStr | Corneal ectasia in mothers of Down syndrome children |
title_full_unstemmed | Corneal ectasia in mothers of Down syndrome children |
title_short | Corneal ectasia in mothers of Down syndrome children |
title_sort | corneal ectasia in mothers of down syndrome children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599422/ https://www.ncbi.nlm.nih.gov/pubmed/34789864 http://dx.doi.org/10.1038/s41598-021-02035-2 |
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