Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1C

Acute myeloid leukemia (AML) is a deadly cancer characterized by an expanded self-renewal capacity that is associated with the accumulation of immature myeloid cells. Emerging evidence shows that methyl-CpG-binding domain protein 2 (MBD2), a DNA methylation reader, often participates in the transcri...

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Detalles Bibliográficos
Autores principales: Zhou, Kuangguo, Zhou, Mi, Cheng, Ling, Chen, Xing, Wang, Xiaomin, Chu, Yajing, Yu, Qilin, Zhang, Shu, Wang, Na, Zhao, Lei, Wang, Di, Huang, Liang, Wang, Congyi, Yuan, Weiping, Zhou, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599466/
https://www.ncbi.nlm.nih.gov/pubmed/34789717
http://dx.doi.org/10.1038/s41389-021-00366-3

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