The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying regulatory mechanism remains poorly characterized. Here we describe a type of early endosome-dependent mitophagy that limits NLRP3 inflammasome activation. Deletion of the endosomal adaptor protein APPL1 impairs mi...

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Detalles Bibliográficos
Autores principales: Wu, Kelvin Ka Lok, Long, KeKao, Lin, Huige, Siu, Parco Ming Fai, Hoo, Ruby Lai Chong, Ye, Dewei, Xu, Aimin, Cheng, Kenneth King Yip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599493/
https://www.ncbi.nlm.nih.gov/pubmed/34789781
http://dx.doi.org/10.1038/s41467-021-26987-1

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