Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides

Saldigones A–C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it’s the first report of isoprenylated flavonoids fr...

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Detalles Bibliográficos
Autores principales: Zhao, Jian-Jun, Li, Song-Yu, Xia, Fan, Hu, Ya-Li, Nian, Yin, Xu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599534/
https://www.ncbi.nlm.nih.gov/pubmed/33893991
http://dx.doi.org/10.1007/s13659-021-00307-y
Descripción
Sumario:Saldigones A–C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it’s the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Ca(v)3.1 low voltage-gated Ca(2+) channel (LVGCC), of which 2 strongly and dose-dependently inhibited Ca(v)3.1 peak current. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00307-y.

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