Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides

Saldigones A–C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it’s the first report of isoprenylated flavonoids fr...

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Autores principales: Zhao, Jian-Jun, Li, Song-Yu, Xia, Fan, Hu, Ya-Li, Nian, Yin, Xu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599534/
https://www.ncbi.nlm.nih.gov/pubmed/33893991
http://dx.doi.org/10.1007/s13659-021-00307-y
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author Zhao, Jian-Jun
Li, Song-Yu
Xia, Fan
Hu, Ya-Li
Nian, Yin
Xu, Gang
author_facet Zhao, Jian-Jun
Li, Song-Yu
Xia, Fan
Hu, Ya-Li
Nian, Yin
Xu, Gang
author_sort Zhao, Jian-Jun
collection PubMed
description Saldigones A–C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it’s the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Ca(v)3.1 low voltage-gated Ca(2+) channel (LVGCC), of which 2 strongly and dose-dependently inhibited Ca(v)3.1 peak current. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00307-y.
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spelling pubmed-85995342021-12-02 Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides Zhao, Jian-Jun Li, Song-Yu Xia, Fan Hu, Ya-Li Nian, Yin Xu, Gang Nat Prod Bioprospect Original Article Saldigones A–C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it’s the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Ca(v)3.1 low voltage-gated Ca(2+) channel (LVGCC), of which 2 strongly and dose-dependently inhibited Ca(v)3.1 peak current. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00307-y. Springer Singapore 2021-04-24 /pmc/articles/PMC8599534/ /pubmed/33893991 http://dx.doi.org/10.1007/s13659-021-00307-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhao, Jian-Jun
Li, Song-Yu
Xia, Fan
Hu, Ya-Li
Nian, Yin
Xu, Gang
Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides
title Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides
title_full Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides
title_fullStr Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides
title_full_unstemmed Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides
title_short Isoprenylated Flavonoids as Ca(v)3.1 Low Voltage-Gated Ca(2+) Channel Inhibitors from Salvia digitaloides
title_sort isoprenylated flavonoids as ca(v)3.1 low voltage-gated ca(2+) channel inhibitors from salvia digitaloides
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599534/
https://www.ncbi.nlm.nih.gov/pubmed/33893991
http://dx.doi.org/10.1007/s13659-021-00307-y
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