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New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599578/ https://www.ncbi.nlm.nih.gov/pubmed/34803715 http://dx.doi.org/10.3389/fphar.2021.774414 |
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author | Shao, Minghai Ye, Chaoyang Bayliss, George Zhuang, Shougang |
author_facet | Shao, Minghai Ye, Chaoyang Bayliss, George Zhuang, Shougang |
author_sort | Shao, Minghai |
collection | PubMed |
description | The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action. |
format | Online Article Text |
id | pubmed-8599578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85995782021-11-19 New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease Shao, Minghai Ye, Chaoyang Bayliss, George Zhuang, Shougang Front Pharmacol Pharmacology The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action. Frontiers Media S.A. 2021-11-04 /pmc/articles/PMC8599578/ /pubmed/34803715 http://dx.doi.org/10.3389/fphar.2021.774414 Text en Copyright © 2021 Shao, Ye, Bayliss and Zhuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Shao, Minghai Ye, Chaoyang Bayliss, George Zhuang, Shougang New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
title | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
title_full | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
title_fullStr | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
title_full_unstemmed | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
title_short | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
title_sort | new insights into the effects of individual chinese herbal medicines on chronic kidney disease |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599578/ https://www.ncbi.nlm.nih.gov/pubmed/34803715 http://dx.doi.org/10.3389/fphar.2021.774414 |
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