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Oligodendrocyte Development and Implication in Perinatal White Matter Injury

Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of...

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Autores principales: Motavaf, Mahsa, Piao, Xianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599582/
https://www.ncbi.nlm.nih.gov/pubmed/34803612
http://dx.doi.org/10.3389/fncel.2021.764486
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author Motavaf, Mahsa
Piao, Xianhua
author_facet Motavaf, Mahsa
Piao, Xianhua
author_sort Motavaf, Mahsa
collection PubMed
description Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of oligodendrocytes (OLs) and cause myelination failure. At present, no treatment options are clinically available to prevent or cure WMI. Given that arrested OL maturation plays a central role in the etiology of perinatal WMI, an increased interest has emerged regarding the functional restoration of these cells as potential therapeutic strategy. Cell transplantation and promoting endogenous oligodendrocyte function are two potential options to address this major unmet need. In this review, we highlight the underlying pathophysiology of WMI with a specific focus on OL biology and their implication for the development of new therapeutic targets.
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spelling pubmed-85995822021-11-19 Oligodendrocyte Development and Implication in Perinatal White Matter Injury Motavaf, Mahsa Piao, Xianhua Front Cell Neurosci Neuroscience Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of oligodendrocytes (OLs) and cause myelination failure. At present, no treatment options are clinically available to prevent or cure WMI. Given that arrested OL maturation plays a central role in the etiology of perinatal WMI, an increased interest has emerged regarding the functional restoration of these cells as potential therapeutic strategy. Cell transplantation and promoting endogenous oligodendrocyte function are two potential options to address this major unmet need. In this review, we highlight the underlying pathophysiology of WMI with a specific focus on OL biology and their implication for the development of new therapeutic targets. Frontiers Media S.A. 2021-11-04 /pmc/articles/PMC8599582/ /pubmed/34803612 http://dx.doi.org/10.3389/fncel.2021.764486 Text en Copyright © 2021 Motavaf and Piao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Motavaf, Mahsa
Piao, Xianhua
Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_full Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_fullStr Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_full_unstemmed Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_short Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_sort oligodendrocyte development and implication in perinatal white matter injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599582/
https://www.ncbi.nlm.nih.gov/pubmed/34803612
http://dx.doi.org/10.3389/fncel.2021.764486
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