RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination

BRCA1-BARD1 heterodimers act in multiple steps during homologous recombination (HR) to ensure the prompt repair of DNA double strand breaks. Dysfunction of the BRCA1 pathway enhances the therapeutic efficiency of poly-(ADP-ribose) polymerase inhibitors (PARPi) in cancers, but the molecular mechanism...

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Detalles Bibliográficos
Autores principales: Zhu, Qian, Huang, Jinzhou, Huang, Hongyang, Li, Huan, Yi, Peiqiang, Kloeber, Jake A., Yuan, Jian, Chen, Yuping, Deng, Min, Luo, Kuntian, Gao, Ming, Guo, Guijie, Tu, Xinyi, Yin, Ping, Zhang, Yong, Su, Jun, Chen, Jiayi, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599684/
https://www.ncbi.nlm.nih.gov/pubmed/34789768
http://dx.doi.org/10.1038/s41467-021-27048-3

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