TGF-β-mediated epithelial–mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma

Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features and TGF-β is a key regulator of EMT. Here, we demonstrate for the first time that TGF-β could elicit EMT in a mouse lung...

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Detalles Bibliográficos
Autores principales: Miyashita, Naoya, Enokido, Takayoshi, Horie, Masafumi, Fukuda, Kensuke, Urushiyama, Hirokazu, Strell, Carina, Brunnström, Hans, Micke, Patrick, Saito, Akira, Nagase, Takahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599691/
https://www.ncbi.nlm.nih.gov/pubmed/34789779
http://dx.doi.org/10.1038/s41598-021-01799-x

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