Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of Ku70 at ser27-ser33 (pKu70) is induced by DNA DSBs and has been shown to regulate cNHEJ activity, but the underlying mechanis...

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Detalles Bibliográficos
Autores principales: Schellenbauer, Amelie, Guilly, Marie-Noelle, Grall, Romain, Le Bars, Romain, Paget, Vincent, Kortulewski, Thierry, Sutcu, Haser, Mathé, Cécile, Hullo, Marie, Biard, Denis, Leteurtre, François, Barroca, Vilma, Corre, Youenn, Irbah, Lamya, Rass, Emilie, Theze, Benoit, Bertrand, Pascale, Demmers, Jeroen A A, Guirouilh-Barbat, Josée, Lopez, Bernard S, Chevillard, Sylvie, Delic, Jozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599715/
https://www.ncbi.nlm.nih.gov/pubmed/34718776
http://dx.doi.org/10.1093/nar/gkab980

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