Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence

Loss of telomeric DNA leads to telomere uncapping, which triggers a persistent, p53-centric DNA damage response that sustains a stable senescence-associated proliferation arrest. Here, we show that in normal cells telomere uncapping triggers a focal telomeric DNA damage response accompanied by a tra...

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Detalles Bibliográficos
Autores principales: Ghadaouia, Sabrina, Olivier, Marc-Alexandre, Martinez, Aurélie, Kientega, Tibila, Qin, Jian, Lambert-Lanteigne, Patrick, Cardin, Guillaume B, Autexier, Chantal, Malaquin, Nicolas, Rodier, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599762/
https://www.ncbi.nlm.nih.gov/pubmed/34725692
http://dx.doi.org/10.1093/nar/gkab965

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