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Constraints on error rate revealed by computational study of G•U tautomerization in translation

In translation, G•U mismatch in codon-anticodon decoding is an error hotspot likely due to transition of G•U from wobble (wb) to Watson-Crick (WC) geometry, which is governed by keto/enol tautomerization (wb-WC reaction). Yet, effects of the ribosome on the wb-WC reaction and its implications for de...

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Detalles Bibliográficos
Autores principales: Kazantsev, Andriy, Ignatova, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599798/
https://www.ncbi.nlm.nih.gov/pubmed/34669948
http://dx.doi.org/10.1093/nar/gkab947

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