ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition

The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures linked to DNA repair defects. Here we demonstrate...

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Detalles Bibliográficos
Autores principales: Bakr, Ali, Hey, Joschka, Sigismondo, Gianluca, Liu, Chun-Shan, Sadik, Ahmed, Goyal, Ashish, Cross, Alice, Iyer, Ramya Lakshmana, Müller, Patrick, Trauernicht, Max, Breuer, Kersten, Lutsik, Pavlo, Opitz, Christiane A, Krijgsveld, Jeroen, Weichenhan, Dieter, Plass, Christoph, Popanda, Odilia, Schmezer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599806/
https://www.ncbi.nlm.nih.gov/pubmed/34718742
http://dx.doi.org/10.1093/nar/gkab964

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