DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified post-transcriptionally, with 2’-O-methylation being most common. However, how U6 2’-O-methylation is regulated remains largely unknown. Here we report that TFIP11, the human homolog of the yeast spliceosome disass...

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Detalles Bibliográficos
Autores principales: Duchemin, Amandine, O’Grady, Tina, Hanache, Sarah, Mereau, Agnès, Thiry, Marc, Wacheul, Ludivine, Michaux, Catherine, Perpète, Eric, Hervouet, Eric, Peixoto, Paul, Ernst, Felix G. M., Audic, Yann, Dequiedt, Franck, Lafontaine, Denis L. J., Mottet, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599867/
https://www.ncbi.nlm.nih.gov/pubmed/34789764
http://dx.doi.org/10.1038/s41467-021-26932-2

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