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Formation and persistence of polyglutamine aggregates in mistranslating cells

In neurodegenerative diseases, including pathologies with well-known causative alleles, genetic factors that modify severity or age of onset are not entirely understood. We recently documented the unexpected prevalence of transfer RNA (tRNA) mutants in the human population, including variants that c...

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Detalles Bibliográficos
Autores principales:	Lant, Jeremy T, Kiri, Rashmi, Duennwald, Martin L, O’Donoghue, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	NAR Breakthrough Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599886/ https://www.ncbi.nlm.nih.gov/pubmed/34718744 http://dx.doi.org/10.1093/nar/gkab898

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