CST does not evict elongating telomerase but prevents initiation by ssDNA binding

The CST complex (CTC1-STN1-TEN1) has been shown to inhibit telomerase extension of the G-strand of telomeres and facilitate the switch to C-strand synthesis by DNA polymerase alpha-primase (pol α-primase). Recently the structure of human CST was solved by cryo-EM, allowing the design of mutant prote...

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Detalles Bibliográficos
Autores principales: Zaug, Arthur J, Lim, Ci Ji, Olson, Conner L, Carilli, Maria T, Goodrich, Karen J, Wuttke, Deborah S, Cech, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599947/
https://www.ncbi.nlm.nih.gov/pubmed/34718732
http://dx.doi.org/10.1093/nar/gkab942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599947/
https://www.ncbi.nlm.nih.gov/pubmed/34718732
http://dx.doi.org/10.1093/nar/gkab942

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