Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1

Aortic aneurysms (AAs) are pathological dilatations of the aorta. Pathogenic variants in genes encoding for proteins of the contractile machinery of vascular smooth muscle cells (VSMCs), genes encoding proteins of the transforming growth factor beta signaling pathway and extracellular matrix (ECM) h...

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Detalles Bibliográficos
Autores principales: Burger, Joyce, Bogunovic, Natalija, de Wagenaar, Nathalie P, Liu, Hui, van Vliet, Nicole, IJpma, Arne, Maugeri, Alessandra, Micha, Dimitra, Verhagen, Hence J M, ten Hagen, Timo L M, Majoor-Krakauer, Danielle, van der Pluijm, Ingrid, Essers, Jeroen, Yeung, Kak K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600030/
https://www.ncbi.nlm.nih.gov/pubmed/34244757
http://dx.doi.org/10.1093/hmg/ddab190

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