The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found...

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Autores principales: Li, Zhigang, Guo, Qingyu, Zhang, Jiaxin, Fu, Zitong, Wang, Yifei, Wang, Tianzhen, Tang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600070/
https://www.ncbi.nlm.nih.gov/pubmed/34804951
http://dx.doi.org/10.3389/fonc.2021.757135
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author Li, Zhigang
Guo, Qingyu
Zhang, Jiaxin
Fu, Zitong
Wang, Yifei
Wang, Tianzhen
Tang, Jing
author_facet Li, Zhigang
Guo, Qingyu
Zhang, Jiaxin
Fu, Zitong
Wang, Yifei
Wang, Tianzhen
Tang, Jing
author_sort Li, Zhigang
collection PubMed
description The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.
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spelling pubmed-86000702021-11-19 The RNA-Binding Motif Protein Family in Cancer: Friend or Foe? Li, Zhigang Guo, Qingyu Zhang, Jiaxin Fu, Zitong Wang, Yifei Wang, Tianzhen Tang, Jing Front Oncol Oncology The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers. Frontiers Media S.A. 2021-11-04 /pmc/articles/PMC8600070/ /pubmed/34804951 http://dx.doi.org/10.3389/fonc.2021.757135 Text en Copyright © 2021 Li, Guo, Zhang, Fu, Wang, Wang and Tang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Zhigang
Guo, Qingyu
Zhang, Jiaxin
Fu, Zitong
Wang, Yifei
Wang, Tianzhen
Tang, Jing
The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_full The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_fullStr The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_full_unstemmed The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_short The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?
title_sort rna-binding motif protein family in cancer: friend or foe?
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600070/
https://www.ncbi.nlm.nih.gov/pubmed/34804951
http://dx.doi.org/10.3389/fonc.2021.757135
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