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Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum

Decreased susceptibilities of the human malaria parasite Plasmodium falciparum towards the endoperoxide antimalarial artemisinin are linked to mutations of residue C580 of PfKelch13, a homologue of the redox sensor Keap1 and other vertebrate BTB-Kelch proteins. Here, we addressed whether mutations a...

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Detalles Bibliográficos
Autores principales:	Schumann, Robin, Bischoff, Eileen, Klaus, Severina, Möhring, Sophie, Flock, Julia, Keller, Sandro, Remans, Kim, Ganter, Markus, Deponte, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600086/ https://www.ncbi.nlm.nih.gov/pubmed/34773836 http://dx.doi.org/10.1016/j.redox.2021.102177

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