The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody)

Peptide display methods are a powerful tool for discovering new ligands of pharmacologically relevant targets. However, the selected ligands often suffer from low affinity. Using phage display, we identified a new bicyclic peptide binder of prostate-specific membrane antigen (PSMA), a metalloproteas...

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Detalles Bibliográficos
Autores principales: Blažková, Kristyna, Beranová, Jana, Hradilek, Martin, Kostka, Libor, Šubr, Vladimír, Etrych, Tomáš, Šácha, Pavel, Konvalinka, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600089/
https://www.ncbi.nlm.nih.gov/pubmed/34710374
http://dx.doi.org/10.1016/j.jbc.2021.101342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600089/
https://www.ncbi.nlm.nih.gov/pubmed/34710374
http://dx.doi.org/10.1016/j.jbc.2021.101342

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