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Generation of Skin Organoids: Potential Opportunities and Challenges

Although several types of human skin substitutes are currently available, they usually do not include important skin appendages such as hair follicles and sweat glands, or various skin-related cells, such as dermal adipocytes and sensory neurons. This highlights the need to improve the in vitro huma...

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Autores principales: Sun, Hui, Zhang, Yi-Xuan, Li, Yu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600117/
https://www.ncbi.nlm.nih.gov/pubmed/34805138
http://dx.doi.org/10.3389/fcell.2021.709824
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author Sun, Hui
Zhang, Yi-Xuan
Li, Yu-Mei
author_facet Sun, Hui
Zhang, Yi-Xuan
Li, Yu-Mei
author_sort Sun, Hui
collection PubMed
description Although several types of human skin substitutes are currently available, they usually do not include important skin appendages such as hair follicles and sweat glands, or various skin-related cells, such as dermal adipocytes and sensory neurons. This highlights the need to improve the in vitro human skin generation model for use as a tool for investigating skin diseases and as a source of cells or tissues for skin regeneration. Skin organoids are generated from stem cells and are expected to possess the complexity and function of natural skin. Here, we summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and then discuss the opportunities and challenges associated with multifunctional skin organoids.
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spelling pubmed-86001172021-11-19 Generation of Skin Organoids: Potential Opportunities and Challenges Sun, Hui Zhang, Yi-Xuan Li, Yu-Mei Front Cell Dev Biol Cell and Developmental Biology Although several types of human skin substitutes are currently available, they usually do not include important skin appendages such as hair follicles and sweat glands, or various skin-related cells, such as dermal adipocytes and sensory neurons. This highlights the need to improve the in vitro human skin generation model for use as a tool for investigating skin diseases and as a source of cells or tissues for skin regeneration. Skin organoids are generated from stem cells and are expected to possess the complexity and function of natural skin. Here, we summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and then discuss the opportunities and challenges associated with multifunctional skin organoids. Frontiers Media S.A. 2021-11-04 /pmc/articles/PMC8600117/ /pubmed/34805138 http://dx.doi.org/10.3389/fcell.2021.709824 Text en Copyright © 2021 Sun, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Sun, Hui
Zhang, Yi-Xuan
Li, Yu-Mei
Generation of Skin Organoids: Potential Opportunities and Challenges
title Generation of Skin Organoids: Potential Opportunities and Challenges
title_full Generation of Skin Organoids: Potential Opportunities and Challenges
title_fullStr Generation of Skin Organoids: Potential Opportunities and Challenges
title_full_unstemmed Generation of Skin Organoids: Potential Opportunities and Challenges
title_short Generation of Skin Organoids: Potential Opportunities and Challenges
title_sort generation of skin organoids: potential opportunities and challenges
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600117/
https://www.ncbi.nlm.nih.gov/pubmed/34805138
http://dx.doi.org/10.3389/fcell.2021.709824
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