Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological features that best correlate with the typical early cognitive decline in...

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Detalles Bibliográficos
Autores principales: Sanchez-Varo, Raquel, Sanchez-Mejias, Elisabeth, Fernandez-Valenzuela, Juan Jose, De Castro, Vanessa, Mejias-Ortega, Marina, Gomez-Arboledas, Angela, Jimenez, Sebastian, Sanchez-Mico, Maria Virtudes, Trujillo-Estrada, Laura, Moreno-Gonzalez, Ines, Baglietto-Vargas, David, Vizuete, Marisa, Davila, Jose Carlos, Vitorica, Javier, Gutierrez, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600261/
https://www.ncbi.nlm.nih.gov/pubmed/34803589
http://dx.doi.org/10.3389/fnins.2021.752594

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