Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a...

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Detalles Bibliográficos
Autores principales: Faltracco, Matteo, Ruijter, Eelco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600370/
https://www.ncbi.nlm.nih.gov/pubmed/34724022
http://dx.doi.org/10.1039/d1ob01966j
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author Faltracco, Matteo
Ruijter, Eelco
author_facet Faltracco, Matteo
Ruijter, Eelco
author_sort Faltracco, Matteo
collection PubMed
description Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.
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spelling pubmed-86003702021-11-23 Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine Faltracco, Matteo Ruijter, Eelco Org Biomol Chem Chemistry Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine. The Royal Society of Chemistry 2021-10-27 /pmc/articles/PMC8600370/ /pubmed/34724022 http://dx.doi.org/10.1039/d1ob01966j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Faltracco, Matteo
Ruijter, Eelco
Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
title Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
title_full Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
title_fullStr Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
title_full_unstemmed Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
title_short Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine
title_sort synthesis of tetracyclic spiroindolines by an interrupted bischler–napieralski reaction: total synthesis of akuammicine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600370/
https://www.ncbi.nlm.nih.gov/pubmed/34724022
http://dx.doi.org/10.1039/d1ob01966j
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AT ruijtereelco synthesisoftetracyclicspiroindolinesbyaninterruptedbischlernapieralskireactiontotalsynthesisofakuammicine

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