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Allergenimmuntherapie bei atopischer Dermatitis

Since the first report of allergen-specific immunotherapy (AIT) by Noon et al. 110 years ago, a multitude of clinical and in vitro studies have been performed to identify the effects of the only curative treatment for allergies. However, in atopic dermatitis (AD), one of the most prevalent skin dise...

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Detalles Bibliográficos
Autores principales: Traidl, Stephan, Werfel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Medizin 2021
Materias:
CME
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600498/
https://www.ncbi.nlm.nih.gov/pubmed/34792615
http://dx.doi.org/10.1007/s00105-021-04909-y
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author Traidl, Stephan
Werfel, Thomas
author_facet Traidl, Stephan
Werfel, Thomas
author_sort Traidl, Stephan
collection PubMed
description Since the first report of allergen-specific immunotherapy (AIT) by Noon et al. 110 years ago, a multitude of clinical and in vitro studies have been performed to identify the effects of the only curative treatment for allergies. However, in atopic dermatitis (AD), one of the most prevalent skin diseases, it is rarely used, despite evidence showing that aeroallergens can contribute to disease exacerbation. This review gives an overview about the studies, meta-analyses, and current guideline recommendations regarding AIT in AD patients. There is a distinct heterogeneity in the study designs, different allergens and application forms, endpoints and patient cohorts, which hinders the comparability of studies. Several trials depict a beneficial effect of AIT in AD patients suggesting that at least a subgroup of patients can benefit from treatment. Further developments in the field of AIT may advocate broader use in AD patients.
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spelling pubmed-86004982021-11-18 Allergenimmuntherapie bei atopischer Dermatitis Traidl, Stephan Werfel, Thomas Hautarzt CME Since the first report of allergen-specific immunotherapy (AIT) by Noon et al. 110 years ago, a multitude of clinical and in vitro studies have been performed to identify the effects of the only curative treatment for allergies. However, in atopic dermatitis (AD), one of the most prevalent skin diseases, it is rarely used, despite evidence showing that aeroallergens can contribute to disease exacerbation. This review gives an overview about the studies, meta-analyses, and current guideline recommendations regarding AIT in AD patients. There is a distinct heterogeneity in the study designs, different allergens and application forms, endpoints and patient cohorts, which hinders the comparability of studies. Several trials depict a beneficial effect of AIT in AD patients suggesting that at least a subgroup of patients can benefit from treatment. Further developments in the field of AIT may advocate broader use in AD patients. Springer Medizin 2021-11-18 2021 /pmc/articles/PMC8600498/ /pubmed/34792615 http://dx.doi.org/10.1007/s00105-021-04909-y Text en © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle CME
Traidl, Stephan
Werfel, Thomas
Allergenimmuntherapie bei atopischer Dermatitis
title Allergenimmuntherapie bei atopischer Dermatitis
title_full Allergenimmuntherapie bei atopischer Dermatitis
title_fullStr Allergenimmuntherapie bei atopischer Dermatitis
title_full_unstemmed Allergenimmuntherapie bei atopischer Dermatitis
title_short Allergenimmuntherapie bei atopischer Dermatitis
title_sort allergenimmuntherapie bei atopischer dermatitis
topic CME
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600498/
https://www.ncbi.nlm.nih.gov/pubmed/34792615
http://dx.doi.org/10.1007/s00105-021-04909-y
work_keys_str_mv AT traidlstephan allergenimmuntherapiebeiatopischerdermatitis
AT werfelthomas allergenimmuntherapiebeiatopischerdermatitis