TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis

OBJECTIVE: Innate lymphoid cells-2 (ILC2) were shown to be involved in the development of lung or hepatic fibrosis. We sought to explore the functional and phenotypic heterogeneity of ILC2 in skin fibrosis within systemic sclerosis (SSc). METHODS: Blood samples and skin biopsies from healthy donor o...

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Detalles Bibliográficos
Autores principales: Laurent, Paôline, Allard, Benoit, Manicki, Pauline, Jolivel, Valérie, Levionnois, Emeline, Jeljeli, Mohamed, Henrot, Pauline, Izotte, Julien, Leleu, Damien, Groppi, Alexis, Seneschal, Julien, Constans, Joel, Chizzolini, Carlo, Richez, Christophe, Duffau, Pierre, Lazaro, Estibaliz, Forcade, Edouard, Schaeverbeke, Thierry, Pradeu, Thomas, Batteux, Frédéric, Blanco, Patrick, Contin-Bordes, Cécile, Truchetet, Marie-Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Systemic Sclerosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600612/
https://www.ncbi.nlm.nih.gov/pubmed/34285051
http://dx.doi.org/10.1136/annrheumdis-2020-219748

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