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CRIS: complete reconstruction of immunoglobulin V-D-J sequences from RNA-seq data

MOTIVATION: B cells display remarkable diversity in producing B-cell receptors through recombination of immunoglobulin (Ig) V-D-J genes. Somatic hypermutation (SHM) of immunoglobulin heavy chain variable (IGHV) genes are used as a prognostic marker in B-cell malignancies. Clinically, IGHV mutation s...

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Detalles Bibliográficos
Autores principales:	Islam, Rashedul, Bilenky, Misha, Weng, Andrew P, Connors, Joseph M, Hirst, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600631/ https://www.ncbi.nlm.nih.gov/pubmed/34806017 http://dx.doi.org/10.1093/bioadv/vbab021

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