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Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts

[Image: see text] Medical shortages during the COVID-19 pandemic saw numerous efforts to 3D print personal protective equipment and treatment supplies. There is, however, little research on the potential biocompatibility of 3D-printed parts using typical polymeric resins as pertaining to volatile or...

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Autores principales: Krechmer, Jordan E., Phillips, Brennan, Chaloux, Nicholas, Shomberg, Russell, Daube, Conner, Manchanda, Gaurav, Murray, Sam, McCarthy, Alex, Fonseca, Rodrigo, Thakkar, Jinen, Loose, Brice, Herndon, Scott C., Jayne, John T., Worsnop, Douglas R., Canagaratna, Manjula R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600644/
https://www.ncbi.nlm.nih.gov/pubmed/34805700
http://dx.doi.org/10.1021/acsomega.1c04695
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author Krechmer, Jordan E.
Phillips, Brennan
Chaloux, Nicholas
Shomberg, Russell
Daube, Conner
Manchanda, Gaurav
Murray, Sam
McCarthy, Alex
Fonseca, Rodrigo
Thakkar, Jinen
Loose, Brice
Herndon, Scott C.
Jayne, John T.
Worsnop, Douglas R.
Canagaratna, Manjula R.
author_facet Krechmer, Jordan E.
Phillips, Brennan
Chaloux, Nicholas
Shomberg, Russell
Daube, Conner
Manchanda, Gaurav
Murray, Sam
McCarthy, Alex
Fonseca, Rodrigo
Thakkar, Jinen
Loose, Brice
Herndon, Scott C.
Jayne, John T.
Worsnop, Douglas R.
Canagaratna, Manjula R.
author_sort Krechmer, Jordan E.
collection PubMed
description [Image: see text] Medical shortages during the COVID-19 pandemic saw numerous efforts to 3D print personal protective equipment and treatment supplies. There is, however, little research on the potential biocompatibility of 3D-printed parts using typical polymeric resins as pertaining to volatile organic compounds (VOCs), which have specific relevance for respiratory circuit equipment. Here, we measured VOCs emitted from freshly printed stereolithography (SLA) replacement medical parts using proton transfer reaction mass spectrometry and infrared differential absorption spectroscopy, and particulates using a scanning mobility particle sizer. We observed emission factors for individual VOCs ranging from ∼0.001 to ∼10 ng cm(–3) min(–1). Emissions were heavily dependent on postprint curing and mildly dependent on the type of SLA resin. Curing reduced the emission of all observed chemicals, and no compounds exceeded the recommended dose of 360 μg/d. VOC emissions steadily decreased for all parts over time, with an average e-folding time scale (time to decrease to 1/e of the starting value) of 2.6 ± 0.9 h.
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spelling pubmed-86006442021-11-19 Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts Krechmer, Jordan E. Phillips, Brennan Chaloux, Nicholas Shomberg, Russell Daube, Conner Manchanda, Gaurav Murray, Sam McCarthy, Alex Fonseca, Rodrigo Thakkar, Jinen Loose, Brice Herndon, Scott C. Jayne, John T. Worsnop, Douglas R. Canagaratna, Manjula R. ACS Omega [Image: see text] Medical shortages during the COVID-19 pandemic saw numerous efforts to 3D print personal protective equipment and treatment supplies. There is, however, little research on the potential biocompatibility of 3D-printed parts using typical polymeric resins as pertaining to volatile organic compounds (VOCs), which have specific relevance for respiratory circuit equipment. Here, we measured VOCs emitted from freshly printed stereolithography (SLA) replacement medical parts using proton transfer reaction mass spectrometry and infrared differential absorption spectroscopy, and particulates using a scanning mobility particle sizer. We observed emission factors for individual VOCs ranging from ∼0.001 to ∼10 ng cm(–3) min(–1). Emissions were heavily dependent on postprint curing and mildly dependent on the type of SLA resin. Curing reduced the emission of all observed chemicals, and no compounds exceeded the recommended dose of 360 μg/d. VOC emissions steadily decreased for all parts over time, with an average e-folding time scale (time to decrease to 1/e of the starting value) of 2.6 ± 0.9 h. American Chemical Society 2021-11-08 /pmc/articles/PMC8600644/ /pubmed/34805700 http://dx.doi.org/10.1021/acsomega.1c04695 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Krechmer, Jordan E.
Phillips, Brennan
Chaloux, Nicholas
Shomberg, Russell
Daube, Conner
Manchanda, Gaurav
Murray, Sam
McCarthy, Alex
Fonseca, Rodrigo
Thakkar, Jinen
Loose, Brice
Herndon, Scott C.
Jayne, John T.
Worsnop, Douglas R.
Canagaratna, Manjula R.
Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts
title Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts
title_full Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts
title_fullStr Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts
title_full_unstemmed Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts
title_short Chemical Emissions from Cured and Uncured 3D-Printed Ventilator Patient Circuit Medical Parts
title_sort chemical emissions from cured and uncured 3d-printed ventilator patient circuit medical parts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600644/
https://www.ncbi.nlm.nih.gov/pubmed/34805700
http://dx.doi.org/10.1021/acsomega.1c04695
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