Advances toward structure-based drug discovery for inflammasome targets

Inflammasome proteins play an important role in many diseases of high unmet need, making them attractive drug targets. However, drug discovery for inflammasome proteins has been challenging in part due to the difficulty in solving high-resolution structures using cryo-EM or crystallography. Recent a...

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Detalles Bibliográficos
Autores principales: Wang, Li, Crackower, Michael A., Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Found in Translation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600719/
https://www.ncbi.nlm.nih.gov/pubmed/34783859
http://dx.doi.org/10.1084/jem.20211147
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author Wang, Li
Crackower, Michael A.
Wu, Hao
author_facet Wang, Li
Crackower, Michael A.
Wu, Hao
author_sort Wang, Li
collection PubMed
description Inflammasome proteins play an important role in many diseases of high unmet need, making them attractive drug targets. However, drug discovery for inflammasome proteins has been challenging in part due to the difficulty in solving high-resolution structures using cryo-EM or crystallography. Recent advances in the structural biology of NLRP3 and NLRP1 have provided the first set of data that proves a promise for structure-based drug design for this important family of targets.
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spelling pubmed-86007192022-07-03 Advances toward structure-based drug discovery for inflammasome targets Wang, Li Crackower, Michael A. Wu, Hao J Exp Med Found in Translation Inflammasome proteins play an important role in many diseases of high unmet need, making them attractive drug targets. However, drug discovery for inflammasome proteins has been challenging in part due to the difficulty in solving high-resolution structures using cryo-EM or crystallography. Recent advances in the structural biology of NLRP3 and NLRP1 have provided the first set of data that proves a promise for structure-based drug design for this important family of targets. Rockefeller University Press 2021-11-16 /pmc/articles/PMC8600719/ /pubmed/34783859 http://dx.doi.org/10.1084/jem.20211147 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Found in Translation
Wang, Li
Crackower, Michael A.
Wu, Hao
Advances toward structure-based drug discovery for inflammasome targets
title Advances toward structure-based drug discovery for inflammasome targets
title_full Advances toward structure-based drug discovery for inflammasome targets
title_fullStr Advances toward structure-based drug discovery for inflammasome targets
title_full_unstemmed Advances toward structure-based drug discovery for inflammasome targets
title_short Advances toward structure-based drug discovery for inflammasome targets
title_sort advances toward structure-based drug discovery for inflammasome targets
topic Found in Translation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600719/
https://www.ncbi.nlm.nih.gov/pubmed/34783859
http://dx.doi.org/10.1084/jem.20211147
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