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X-ray repair cross-complementing protein 1 (XRCC1) loss promotes β-lapachone –induced apoptosis in pancreatic cancer cells

BACKGROUND: β-lapachone (β-lap), the NQO1 bioactivatable drug, is thought to be a promising anticancer agent. However, the toxic side effects of β-lap limit the drug use, highlighting the need for a thorough understanding of β-lap’s mechanism of action. β-lap undergoes NQO1-dependent futile redox cy...

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Detalles Bibliográficos
Autores principales:	Zheng, Yansong, Zhang, Hengce, Guo, Yueting, Chen, Yuan, Chen, Hanglong, Liu, Yingchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600733/ https://www.ncbi.nlm.nih.gov/pubmed/34789190 http://dx.doi.org/10.1186/s12885-021-08979-y

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