A SUMOylation wave to anchor the genome

Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103036) identify a phosph...

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Detalles Bibliográficos
Autor principal: Marston, Adele L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600798/
https://www.ncbi.nlm.nih.gov/pubmed/34787674
http://dx.doi.org/10.1083/jcb.202110031
Descripción
Sumario:Chromatin tethers to the nuclear envelope are lost during mitosis to facilitate chromosome segregation. How these connections are reestablished to ensure functional genome organization in interphase is unclear. Ptak et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202103036) identify a phosphorylation and SUMOylation-dependent cascade that links chromatin to the nuclear membrane during late mitosis.

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