Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap

Mucormycosis has recently been recognized as a severe complication of COVID-19 with high fatality rates. We report a fatal case of COVID-19 associated mucormycosis (CAM) in a non-diabetic immunocompromised patient, who was first misdiagnosed and treated for COVID-19 associated aspergillosis (CAPA)....

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Autores principales: Crone, Cornelia Geisler, Helweg-Larsen, Jannik, Steensen, Morten, Arendrup, Maiken Cavling, Helleberg, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Masson SAS on behalf of SFMM. 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600800/
https://www.ncbi.nlm.nih.gov/pubmed/34826672
http://dx.doi.org/10.1016/j.mycmed.2021.101228
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author Crone, Cornelia Geisler
Helweg-Larsen, Jannik
Steensen, Morten
Arendrup, Maiken Cavling
Helleberg, Marie
author_facet Crone, Cornelia Geisler
Helweg-Larsen, Jannik
Steensen, Morten
Arendrup, Maiken Cavling
Helleberg, Marie
author_sort Crone, Cornelia Geisler
collection PubMed
description Mucormycosis has recently been recognized as a severe complication of COVID-19 with high fatality rates. We report a fatal case of COVID-19 associated mucormycosis (CAM) in a non-diabetic immunocompromised patient, who was first misdiagnosed and treated for COVID-19 associated aspergillosis (CAPA). The risk factors and initial clinical presentation of CAPA and CAM are similar, but CAM has a more aggressive course and CAPA and CAM are treated differently. Dedicated diagnostic workup is essential to ensure early treatment of CAM with surgical debridement and targeted antifungal therapy.
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spelling pubmed-86008002021-11-18 Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap Crone, Cornelia Geisler Helweg-Larsen, Jannik Steensen, Morten Arendrup, Maiken Cavling Helleberg, Marie J Mycol Med Case Report Mucormycosis has recently been recognized as a severe complication of COVID-19 with high fatality rates. We report a fatal case of COVID-19 associated mucormycosis (CAM) in a non-diabetic immunocompromised patient, who was first misdiagnosed and treated for COVID-19 associated aspergillosis (CAPA). The risk factors and initial clinical presentation of CAPA and CAM are similar, but CAM has a more aggressive course and CAPA and CAM are treated differently. Dedicated diagnostic workup is essential to ensure early treatment of CAM with surgical debridement and targeted antifungal therapy. The Author(s). Published by Elsevier Masson SAS on behalf of SFMM. 2022-03 2021-11-18 /pmc/articles/PMC8600800/ /pubmed/34826672 http://dx.doi.org/10.1016/j.mycmed.2021.101228 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Crone, Cornelia Geisler
Helweg-Larsen, Jannik
Steensen, Morten
Arendrup, Maiken Cavling
Helleberg, Marie
Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap
title Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap
title_full Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap
title_fullStr Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap
title_full_unstemmed Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap
title_short Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap
title_sort pulmonary mucormycosis in the aftermath of critical covid-19 in an immunocompromised patient: mind the diagnostic gap
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600800/
https://www.ncbi.nlm.nih.gov/pubmed/34826672
http://dx.doi.org/10.1016/j.mycmed.2021.101228
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