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Circular RNAs in acute myeloid leukemia

Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inherent and acquired resistance to current therapies remains an unsolved clinical problem. While...

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Autores principales: Singh, Vijendra, Uddin, Mohammed Hafiz, Zonder, Jeffrey A., Azmi, Asfar S., Balasubramanian, Suresh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600814/
https://www.ncbi.nlm.nih.gov/pubmed/34794438
http://dx.doi.org/10.1186/s12943-021-01446-z
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author Singh, Vijendra
Uddin, Mohammed Hafiz
Zonder, Jeffrey A.
Azmi, Asfar S.
Balasubramanian, Suresh Kumar
author_facet Singh, Vijendra
Uddin, Mohammed Hafiz
Zonder, Jeffrey A.
Azmi, Asfar S.
Balasubramanian, Suresh Kumar
author_sort Singh, Vijendra
collection PubMed
description Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inherent and acquired resistance to current therapies remains an unsolved clinical problem. While current diagnostic modalities are primarily defined by gross morphology, cytogenetics, and to an extent, by deep targeted gene sequencing, there is an ongoing demand to identify newer diagnostic, therapeutic and prognostic biomarkers for AML. Recent interest in exploring the role of circular RNA (circRNA) in elucidating AML biology and therapy resistance has been promising. This review discerns the circular RNAs’ evolving role on the same scientific premise and attempts to identify its potential in managing AML.
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spelling pubmed-86008142021-11-19 Circular RNAs in acute myeloid leukemia Singh, Vijendra Uddin, Mohammed Hafiz Zonder, Jeffrey A. Azmi, Asfar S. Balasubramanian, Suresh Kumar Mol Cancer Review Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inherent and acquired resistance to current therapies remains an unsolved clinical problem. While current diagnostic modalities are primarily defined by gross morphology, cytogenetics, and to an extent, by deep targeted gene sequencing, there is an ongoing demand to identify newer diagnostic, therapeutic and prognostic biomarkers for AML. Recent interest in exploring the role of circular RNA (circRNA) in elucidating AML biology and therapy resistance has been promising. This review discerns the circular RNAs’ evolving role on the same scientific premise and attempts to identify its potential in managing AML. BioMed Central 2021-11-18 /pmc/articles/PMC8600814/ /pubmed/34794438 http://dx.doi.org/10.1186/s12943-021-01446-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Singh, Vijendra
Uddin, Mohammed Hafiz
Zonder, Jeffrey A.
Azmi, Asfar S.
Balasubramanian, Suresh Kumar
Circular RNAs in acute myeloid leukemia
title Circular RNAs in acute myeloid leukemia
title_full Circular RNAs in acute myeloid leukemia
title_fullStr Circular RNAs in acute myeloid leukemia
title_full_unstemmed Circular RNAs in acute myeloid leukemia
title_short Circular RNAs in acute myeloid leukemia
title_sort circular rnas in acute myeloid leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600814/
https://www.ncbi.nlm.nih.gov/pubmed/34794438
http://dx.doi.org/10.1186/s12943-021-01446-z
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