RNA m6A methylation regulators in ovarian cancer

N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases...

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Autores principales: Guo, Jialu, Zheng, Jianfeng, Zhang, Huizhi, Tong, Jinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600856/
https://www.ncbi.nlm.nih.gov/pubmed/34794452
http://dx.doi.org/10.1186/s12935-021-02318-8
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author Guo, Jialu
Zheng, Jianfeng
Zhang, Huizhi
Tong, Jinyi
author_facet Guo, Jialu
Zheng, Jianfeng
Zhang, Huizhi
Tong, Jinyi
author_sort Guo, Jialu
collection PubMed
description N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC) is a common but highly fatal malignancy in female. Increasing evidence shows that changes in m6A levels and the dysregulation of m6A regulators are associated with the occurrence, development or prognosis of OC. In this review, the latest studies on m6A and its regulators in OC have been summarized, and we focus on the key role of m6A modification in the development and progression of OC. Additionally, we also discuss the potential use of m6A modification and its regulators in the diagnosis and treatment of OC.
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spelling pubmed-86008562021-11-19 RNA m6A methylation regulators in ovarian cancer Guo, Jialu Zheng, Jianfeng Zhang, Huizhi Tong, Jinyi Cancer Cell Int Review N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in epigenetics. M6A modification is dynamically regulated by methyltransferases, demethylases and RNA-binding proteins. Ovarian cancer (OC) is a common but highly fatal malignancy in female. Increasing evidence shows that changes in m6A levels and the dysregulation of m6A regulators are associated with the occurrence, development or prognosis of OC. In this review, the latest studies on m6A and its regulators in OC have been summarized, and we focus on the key role of m6A modification in the development and progression of OC. Additionally, we also discuss the potential use of m6A modification and its regulators in the diagnosis and treatment of OC. BioMed Central 2021-11-18 /pmc/articles/PMC8600856/ /pubmed/34794452 http://dx.doi.org/10.1186/s12935-021-02318-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guo, Jialu
Zheng, Jianfeng
Zhang, Huizhi
Tong, Jinyi
RNA m6A methylation regulators in ovarian cancer
title RNA m6A methylation regulators in ovarian cancer
title_full RNA m6A methylation regulators in ovarian cancer
title_fullStr RNA m6A methylation regulators in ovarian cancer
title_full_unstemmed RNA m6A methylation regulators in ovarian cancer
title_short RNA m6A methylation regulators in ovarian cancer
title_sort rna m6a methylation regulators in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600856/
https://www.ncbi.nlm.nih.gov/pubmed/34794452
http://dx.doi.org/10.1186/s12935-021-02318-8
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AT zhengjianfeng rnam6amethylationregulatorsinovariancancer
AT zhanghuizhi rnam6amethylationregulatorsinovariancancer
AT tongjinyi rnam6amethylationregulatorsinovariancancer

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