Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies

Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell products have been approved by the US Food and Drug Administration (FDA). Nevertheless, some significant toxicities pose great...

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Detalles Bibliográficos
Autores principales: Xiao, Xinyi, Huang, Shengkang, Chen, Sifei, Wang, Yazhuo, Sun, Qihang, Xu, Xinjie, Li, Yuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600921/
https://www.ncbi.nlm.nih.gov/pubmed/34794490
http://dx.doi.org/10.1186/s13046-021-02148-6

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