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Multiomics uncovers developing immunological lineages in human [Image: see text]
The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across specie...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600952/ https://www.ncbi.nlm.nih.gov/pubmed/33569778 http://dx.doi.org/10.1002/eji.202048769 |
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author | Stephenson, Emily Webb, Simone Haniffa, Muzlifah |
author_facet | Stephenson, Emily Webb, Simone Haniffa, Muzlifah |
author_sort | Stephenson, Emily |
collection | PubMed |
description | The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across species. The advent of multiomic single‐cell technologies and an increase in human developmental tissue biobank resources have facilitated single‐cell multiomic studies focused on human immune development. A critical question in the near future is "How do we best reconcile scientific findings across multiple omic modalities, developmental time, and organismic space?" In this review, we discuss the application of single‐cell multiomic technologies to unravel the major cellular lineages in the prenatal human immune system. We also identify key areas where the combined power of multiomics technologies can be leveraged to address specific immunological gaps in our current knowledge and explore new research horizons in human development. |
format | Online Article Text |
id | pubmed-8600952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86009522021-11-23 Multiomics uncovers developing immunological lineages in human [Image: see text] Stephenson, Emily Webb, Simone Haniffa, Muzlifah Eur J Immunol Highlights The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across species. The advent of multiomic single‐cell technologies and an increase in human developmental tissue biobank resources have facilitated single‐cell multiomic studies focused on human immune development. A critical question in the near future is "How do we best reconcile scientific findings across multiple omic modalities, developmental time, and organismic space?" In this review, we discuss the application of single‐cell multiomic technologies to unravel the major cellular lineages in the prenatal human immune system. We also identify key areas where the combined power of multiomics technologies can be leveraged to address specific immunological gaps in our current knowledge and explore new research horizons in human development. John Wiley and Sons Inc. 2021-03-10 2021-04 /pmc/articles/PMC8600952/ /pubmed/33569778 http://dx.doi.org/10.1002/eji.202048769 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Highlights Stephenson, Emily Webb, Simone Haniffa, Muzlifah Multiomics uncovers developing immunological lineages in human [Image: see text] |
title | Multiomics uncovers developing immunological lineages in human [Image: see text]
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title_full | Multiomics uncovers developing immunological lineages in human [Image: see text]
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title_fullStr | Multiomics uncovers developing immunological lineages in human [Image: see text]
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title_full_unstemmed | Multiomics uncovers developing immunological lineages in human [Image: see text]
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title_short | Multiomics uncovers developing immunological lineages in human [Image: see text]
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title_sort | multiomics uncovers developing immunological lineages in human [image: see text] |
topic | Highlights |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600952/ https://www.ncbi.nlm.nih.gov/pubmed/33569778 http://dx.doi.org/10.1002/eji.202048769 |
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